At what point do you end a relationship? People who ask this question already know the answer. I have 3 giveaways of when it's time to exit stage left: 1. When you've done all you can to salvage it. In that case, let him/her go. No sense in looking crazy. 2. When you have to ask that question, it's that time. 3. The point of no return. For many people, the point of no return comes sooner rather than later.
